多草药修复配方的成分分析及其在烧伤伤愈合中的药理机制
Xiangwei Qu1, Shanqin You1, Zhaoxiang Zeng1
1School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.
概括
中国传统医学中的Jiusheng伤口修复食谱 (JSWR) 通过促进原和血管形成,同时减少炎症,加速伤口愈合. 它的化学构成和机制得到了阐明,为进一步开发铺平了道路.
科学领域:
- 传统中国医药 传统中国医药
- 药理学 药理学是指药理学的学科.
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 生伤口修复食谱 (JSWR) 是一种传统中医民间药物,用于治疗烧伤和伤.
- 精确的化学成分和JSWR的潜在药理机制以前是未定义的.
- 了解JSWR的组成和作用对于其临床应用和科学验证至关重要.
研究的目的:
- 为了全面分析JSWR的化学成分.
- 在伤口愈合模型中研究JSWR的药理作用和机制.
- 阐明涉及JSWR介导伤口修复的分子途径.
主要方法:
- 超高性能液态色谱与四极飞行时间质谱学 (UPLC-QTOF-MS) 结合,用于化学分析.
- 一个使用组织学和免疫组织化学分析的小鼠伤口愈合模型.
- 代谢分析以探索潜在的药理机制.
主要成果:
- 在JSWR中识别和描述530个组件.
- 在接受JSWR治疗的小鼠中观察到伤口愈合速度的显著加快.
- 通过减少TNF-α和IL-6水平,增强原I/III和CD31的表达,并减少COX-2的表达,JSWR显示出抗炎作用.
- 代谢分析确定了19种关键代谢物和关键代谢途径.
结论:
- 通过增强原体沉积和血管生成,JSWR有效促进伤口愈合.
- JSWR表现出抗炎性质,有助于其治疗疗效.
- 对JSWR机制的进一步研究将支持其临床应用和开发.
相关概念视频
Phases of Wound Repair
5.7K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
5.7K
Overview of Regeneration and Repair
3.9K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
3.9K
Burn Injuries
2.3K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.3K
Clinical Applications of Epidermal Stem Cells
2.6K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.6K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
4.4K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
4.4K


