治疗中的聚焦超声波:当前的应用和未来的方向
Stereotactic and functional neurosurgery
|April 23, 2025
概括
聚焦超声波 (FUS) 为治疗提供了一种不那么侵入性的替代方案,在废除和神经调节方面具有应用. 研究正在扩大,包括声遗传学和药物输送,以改善临床翻译.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 生物医学工程 生物医学工程
背景情况:
- 影响全球1%的人口,许多患者对当前治疗不耐药.
- 传统的手术涉及具有重大风险的侵入性切除.
- 聚焦超声波 (FUS) 是一种有希望的,不那么侵入性的,以图像为导向的治疗方法.
研究的目的:
- 系统地审查FUS在治疗中的临床前和临床应用.
- 为了确定当前的挑战和未来的研究方向在的FUS.
主要方法:
- 对的FUS进行临床前和临床研究的系统文献搜索.
- 包括研究FUS. ablative,神经调节和血脑屏障开放应用的研究.
- 排除非症表示的FUS应用程序.
主要成果:
- 审查了55项研究 (46篇文章,9项正在进行的试验).
- 10项研究重点研究了废除性FUS (包括临床前,试点和正在进行的临床试验).
- 30项研究研究了神经调节性FUS,其中大多数是在临床前阶段.
- 15项临床前研究探讨了FUS介导的血脑屏障开放.
结论:
- 在临床上,FUS用于中针对性脑切除和神经调节.
- 新兴应用包括声遗传学和通过血脑屏障开放的药物输送.
- 需要进一步的研究来应对实施挑战,并推进临床翻译.
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