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采酸载纳米颗粒作为内牙抗菌剂:一个体外研究

Amir Isam Omer Ibrahim^1,2, Desigar Moodley^2,3, Ernest Maboza⁴

¹Department of Restorative Dental Sciences, College of Dentistry, King Faisal University, Al-Ahsa, Saudi Arabia.

European journal of dentistry

|April 23, 2025

概括

一种新型的基托桑纳米颗粒 (Ch-Np) - 泽奥利特-Y纳米复合物显示出对内牙病原体具有强大的抗菌活性. 这种生物活性剂在存在组织抑制剂的情况下仍然有效,并且不表现出细胞毒性,这表明它有可能用于牙科应用.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
牙周内科医院牙周内科医院牙周内科医院
微生物学微生物学

背景情况:

开发有效的抗微生物药物用于内牙治疗对于预防和管理根管感染至关重要.
素纳米颗粒 (Ch-Np) 已经显示出抗菌性质,但它们的应用可能受到稳定性和传递挑战的限制.
泽奥利特-Y具有适合纳米粒子加载的多孔结构,有可能提高活性剂的有效性和受控释放.

研究的目的:

通过将电喷的奇多纳米颗粒 (Ch-Np) 装入烯酸-Y,以合成一种生物活性纳米复合材料,用于作为内抗菌剂.
为了评估Ch-Np-Zeolite纳米复合物的抗菌活性,针对关键的内牙病原体,Streptococcus mutans和Enterococcus faecalis.
评估组织抑制剂的影响和开发的纳米复合材料的细胞毒性.

主要方法:

素纳米颗粒 (Ch-Np) 被电喷涂并装入-Y.
使用高分辨率扫描电子显微镜 (HR-SEM) 和能量分散式X射线光谱 (EDS) 进行了表征.
通过亚格扩散和时间杀死试验测试了抗菌活性,在3T3纤维细胞上使用MTT试验评估了细胞毒性.

主要成果:

HR-SEM和EDS证实了-Np成功装入青石-Y,保留了青石的结构和元素组成.
这种Ch-Np-Zeolite纳米复合物对S.表现出显著的抗菌活性. 变种 和E. ,在存在组织抑制剂的情况下完全根除.
该纳米复合材料表现出极好的生物相容性,显著促进3T3纤维细胞细胞生长,表明缺乏细胞毒性.

结论:

采酸载荷的Ch-Np纳米复合物是内牙应用的有前途的生物活性剂.
纳米复合材料有效地对抗主要的内牙病原体,即使在具有挑战性的条件下使用组织抑制剂.
该材料的生物相容性支持其在临床内牙治疗中的潜在用途.

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