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在肺栓塞发生三个月后,儿科患者呼吸障碍的风险增加
Abidan Abulimiti1, Lydia S Robson2, James A Pawelczyk3
1Institute for Exercise and Environmental Medicine, University of Texas Southwestern Medical Center and Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA.
Respiratory medicine
|April 23, 2025
概括
患有肺栓塞 (PE) 病史的儿科患者面临患有呼吸障碍的风险明显更高. 这一发现强调了在诊断儿童呼吸短促时考虑先前PE的重要性.
科学领域:
- 儿科医学 儿科医学
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
背景情况:
- 肺栓塞 (PE) 是儿童的一种严重疾病.
- 呼吸障碍是儿童群体中各种原因的常见症状.
研究的目的:
- 为了确定先前肺栓塞 (PE) 的儿科患者是否有呼吸障碍诊断的可能性增加.
- 在青少年和年轻成年人中评估先前PE和随后呼吸障碍诊断之间的关联.
主要方法:
- 使用了来自TriNetX平台的非身份化数据,包括UTSW和研究网络.
- 确定了8至21岁的儿科患者,诊断为PE (ICD-10-CM I26) 和呼吸障碍 (ICD-10-CM R06.0).
- 进行统计分析,以评估患有PE病史的患者呼吸障碍诊断的风险.
主要成果:
- 患有先前PE诊断的患者在UTSW (OR 4.57) 和研究网络 (OR 6.57) 显示呼吸障碍诊断的风险明显更高.
- 在两个网络中,PE和呼吸障碍之间的关联在统计上是显著的 (p < 0.0001).
- 与研究网络中的男性相比,患有PE诊断的女性患呼吸障碍的风险明显更高 (p < 0.0001).
结论:
- 以前的PE是儿科患者呼吸障碍诊断的独立风险因素.
- 临床医生在评估儿科患者呼吸障碍时,在排除其他原因后,应考虑PE病史.
- 这些发现强调了PE在儿科人口中对呼吸系统的长期影响.
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