渐进性抵抗训练对渐进性多发性硬化症患者心血管风险因素的影响
Arianne S Gravesteijn1, Heleen Beckerman2, Marloes Willig3
1MS Center Amsterdam, Rehabilitation Medicine, Amsterdam UMC location Vrije Universiteit, Amsterdam, The Netherlands; Amsterdam Neuroscience Research Institute, Neuroinfection & Neuroinflammation, Amsterdam, The Netherlands; Amsterdam Movement Sciences Research Institute, Rehabilitation & Development, Amsterdam, The Netherlands.
Archives of physical medicine and rehabilitation
|April 23, 2025
概括
渐进性抵抗训练没有改善二次渐进性多发性硬化症患者的心血管风险因素. 风险因素的自然波动是最小的,这表明这个人群的变化有限.
科学领域:
- 心血管健康 心血管健康
- 神经学 神经学
- 运动科学 运动科学
背景情况:
- 二次渐进性多发性硬化症 (SPMS) 对心血管风险管理提出了挑战.
- 了解心血管风险因素的自然波动对于干预研究至关重要.
研究的目的:
- 在SPMS中评估16周内心血管风险因子的变化.
- 评估16周的渐进性抵抗训练 (PRT) 干预对SPMS心血管风险的影响.
主要方法:
- 一个单臂非随机临床试验的二次分析.
- 30名SPMS参与者接受了为期16周的PRT计划.
- 心血管风险因素在基线,16周和32周被测量.
主要成果:
- PRT显著改善了肌肉力量,但没有改变心血管风险参数.
- 心血管风险因素的自然波动通常很小 (ICC 0.717-0.983),除了静缩血压 (ICC 0.471).
结论:
- 16周的PRT计划没有改善SPMS患者的心血管风险.
- 心血管风险因素在这个SPMS队列中显示出有限的自然波动.
- 基线心血管风险与荷兰一般人口规范相当.
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