长时间禁食促进全身炎症和血小板激活在人类:一个医疗监督,仅用水禁食和再养的研究
Serena Commissati1, Maria Lastra Cagigas2, Andrius Masedunskas2
1Department of Medicine, University of Verona, Italy.
Molecular metabolism
|April 23, 2025
概括
长期禁食 (PF) 诱导了显著的血蛋白质组适应,包括减少粉样β和增强脂质代谢. 然而,它也会引发急性炎症反应,因此需要进一步研究长期影响.
科学领域:
- 代谢学 代谢学 代谢学
- 蛋白质组学是指蛋白质组学.
- 人体生理学 人体生理学
背景情况:
- 长期禁食 (PF) 正在作为一种健康干预手段获得越来越多的兴趣.
- 对于PF对血蛋白质组的生物学影响尚不清楚.
研究的目的:
- 为了研究医疗监督的仅含水的长时间禁食对血蛋白质组的影响.
- 为了确定与PF相关的分子适应和潜在风险.
主要方法:
- 在20名中年志愿者中,医疗监督的纯水禁食 (平均9.8天).
- 非向性血蛋白质组学 (1,317种蛋白质) 和回顾性队列分析 (1,422个人).
- 用于验证急性阶段反应标志物的ELISA.
主要成果:
- PF导致7.7%的体重减轻,并增加了β-基酸盐 (BHB).
- 蛋白质组学揭示了肌肉/骨的保存,增强了溶酶体生物发生,增加了脂质代谢,并减少了粉样β (Aβ40,Aβ42).
- 观察到急性炎症反应,在较大的队列中证实了高C反应蛋白 (CRP),肝素,中基因和IL-8的水平.
结论:
- PF诱导复杂的蛋白质基因适应,包括对粉样蛋白和脂质代谢的有益影响.
- 在PF期间的短暂急性炎症反应可能会对心脏代谢健康产生影响.
- 需要进一步的研究来了解PF的长期临床结果.
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