绘制地图知识景观和主题 乳腺癌干细胞的趋势:一项基于数据挖掘的综合性研究
Kunming Cheng1, Hui Di2, Chunchun Wu3
1Department of Intensive Care Unit, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Annals of surgical oncology
|April 23, 2025
概括
这项文献计量分析揭示了全球对乳腺癌干细胞 (BCSCs) 的研究兴趣日益增长. 关键领域包括生物标志物,信号通路和治疗耐药性,铁亡和瘤微环境的新兴趋势.
科学领域:
- 在瘤学瘤学.
- 生物医学研究生物医学研究
- 图书统计学 图书统计学
背景情况:
- 乳腺癌干细胞 (BCSCs) 在治疗中存在重大挑战,有助于耐药性,复发和转移.
- 准BCSCs是一个关键的治疗策略,但研究领域仍未得到充分探索.
- 没有一项文献计量分析能够全面地绘制出BCSC研究领域.
研究的目的:
- 进行第一个对乳腺癌干细胞 (BCSC) 研究的文献分析.
- 绘制全球研究成果的地图,确定主要贡献者,分析研究趋势和热点.
- 在BCSC研究中为未来的研究方向和政策制定提供见解.
主要方法:
- 从1998年到2023年,对1771篇与BCSC相关的出版物进行了图书统计分析.
- 从科学网络核心集合中提取的数据.
- 分析使用VOSviewer,CiteSpace和两个在线平台进行.
主要成果:
- BCSC出版物的显著增加,年增长率为18.4%.
- 中国和美国是主要的贡献者,密歇根大学系统是最多产的机构.
- 目前的研究重点是干性,生物标志物,信号通路,治疗向,耐药性和微环境.
- 新兴的研究领域包括ferroptosis,GLI1,分子对接,瘤微环境和三阴性乳腺癌.
- 发现的关键基因包括TGFB1,STAT3,MYC,GAPDH和INS.
结论:
- 这项研究提供了BCSC研究的第一个全面的文献统计概述.
- 确定当前的研究前沿和该领域的新兴趋势.
- 作为研究人员和政策制定者指导未来BCSC研究工作的宝贵参考.
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