在怀孕期间接种疫苗,以保护新生儿
Victoria Male1, Christine E Jones2,3
1Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. v.male@imperial.ac.uk.
Nature reviews. Immunology
|April 24, 2025
概括
在怀孕期间对母亲进行疫苗接种是保护新生儿免受传染病的重要策略. 这种方法补充了婴儿直接免疫接种,增强新生儿对严重感染的免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 新生儿健康 新生儿健康
背景情况:
- 新生儿很容易感染传染病,需要有效的保护策略.
- 开发对新生儿安全有效的疫苗存在重大挑战.
- 通过胎盘转移的母体抗体提供了被动免疫力,突出了母体疫苗接种的潜力.
研究的目的:
- 审查当前在怀孕期间和新生儿接种的疫苗.
- 讨论正在开发的用于保护新生儿的疫苗.
- 识别针对母婴免疫计划的疫苗接种和接种方面的挑战.
主要方法:
- 对现有的孕妇和新生儿疫苗的文献综述.
- 对针对新生儿感染的批准和新兴疫苗的分析.
- 讨论疫苗实施和可访问性方面的挑战.
主要成果:
- 目前,有限的疫苗已获得许可,可直接在新生儿中使用 (乙型肝炎,结核病).
- 孕产妇接种疫苗 (如破伤风,百日咳,流感,COVID-19) 提供对新生儿的间接保护.
- 针对呼吸道同胞细胞病毒 (RSV) 和B组链球菌 (GBS) 的新疫苗正在出现,用于产前管理.
结论:
- 怀孕期间接种疫苗是保护新生儿免受传染病的成功策略.
- 目前正在进行的研发正在扩大母婴使用的疫苗组合.
- 解决疫苗接种和接种方面的挑战对于最大限度地提高公共卫生效益至关重要.
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