上腺素通过PKC/NFκB介导的NOX2上调节促进了血管前进性纤维细胞中的氧化应激

Yi-Ming Wang1, Hong-Ke Dong1, Min Dai1

  • 1Department of Physiology, Nanjing Medical University, Nanjing, People's Republic of China.

概括

上腺素 (NE) 通过氧化应激驱动血管顺序性纤维细胞 (VAF) 的增殖和迁移. 这一过程涉及NADPH氧化酶2 (NOX2) 激活,由α受体,蛋白激酶C (PKC) 和NF-kappaB (NFκB) 介导.

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