患有下垂体神经内分泌瘤的患者的甲状腺疾病
Nan Fengjuan1, Mu Chengzhi2, Yu Shengyuan2
1Department of Gynecology Ultrasound, Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Clinical endocrinology
|April 24, 2025
概括
甲状腺疾病,包括较大的甲状腺体积,和结节,在生长激素-垂体神经内分泌瘤 (GH-PitNET) 患者中很常见. 对PitNETs的治疗可以改善这些甲状腺疾病,建议进行常规监测.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 甲状腺学 甲状腺学
背景情况:
- 甲状腺疾病经常与下垂体神经内分泌瘤 (PitNETs) 发生,这是由于下垂体-下垂体-甲状腺轴.
- 现有的研究尚未充分探索不同PitNET亚型与甲状腺疾病之间的特定关联.
- 本研究旨在对各种PitNET亚型的甲状腺疾病进行表征,并评估治疗影响.
研究的目的:
- 为了研究患有不同类型的PitNETs的患者甲状腺疾病的患病率和特征.
- 评估PitNET治疗对先前存在的甲状腺异常的影响.
主要方法:
- 对168名PitNET患者的回顾性分析,分为分泌生长激素 (GH),益生菌瘤 (PRL) 和非功能性 (NF) 组.
- 甲状腺超声波,垂体功能测试和甲状腺功能测试在PitNET治疗前和治疗后一年进行.
主要成果:
- 与其他组相比,GH-PitNET患者的甲状腺体体积显著增加,喉和多重结节的发病率更高.
- 在PRL-PitNET患者中,自身免疫性甲状腺炎的患病率较高,甲状腺过氧化酶抗体 (TPOAb) 和甲状腺球蛋白抗体 (TGAb) 的升高.
- 在患有自身免疫性甲状腺炎的患者中,PitNET治疗导致甲状腺体体积,发病率和抗体水平显著降低.
结论:
- 增长激素分泌的PitNETs与增加的甲状腺体量,喉和多个结节密切相关.
- 益生菌瘤更频繁地与自身免疫性甲状腺炎有关.
- 治疗PitNETs有效地缓解了相关的甲状腺表现,这强调了这些患者需要定期进行甲状腺监测的必要性.
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