血液病患者感染流感病毒的危险因素
Hirotomo Nakashima1, Shin-Ichiro Fujiwara1,2, Seina Honda1
1Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.
流感病毒感染 (IVI) 是患有血液疾病的患者的重大风险. 移植后患者面临的IVI率最高,随着年龄的增长,并发症风险增加.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 流感病毒感染 (IVI) 对免疫力低下的个体构成严重威胁,特别是那些患有血液病的人.
- 在患有良性和恶性血液病症的患者中,IVI的确切发生率和风险因素仍未完全定义.
研究的目的:
- 确定患有血液病的患者流感病毒感染 (IVI) 的发病率和风险因素.
- 在这个患者群体中,评估IVI后下呼吸道感染 (LRTI) 进展的风险.
主要方法:
- 从2012年到2019年,对患有血液病的患者进行了回顾性分析,这些患者参加了血液病门诊部门的血液病诊所.
- 计算每1000人/年的IVI发病率.
- 单变物流回归分析以确定与LRTI相关的因素.
主要成果:
- 在4864名门诊患者中,共发现了81例 (1.67%) 的IVI.
- 整体IVI发生率为每1000人/年4.82,在异构移植后的患者中发生率显著更高 (1000人/年21.0).
- 七名患者 (8.6%) 患上下呼吸道感染 (LRTI);晚年 (≥60岁) 和中度至重度的慢性移植对宿主疾病 (GVHD) 与LRTI有关.
结论:
- 接受造血干细胞移植的患者患流感病毒感染的风险较高.
- 晚年增大了IVI对血液病患者的影响.
- 针对IVI的有针对性的监测和预防策略对于免疫功能低下的血液病患者至关重要,特别是移植后患者和老年人.
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