光生物调节和口腔肠道微生物群轴:治疗潜力和挑战
Neda Hakimiha1, Somayeh Jahani Sherafat1, E-Liisa Laakso2,3
1Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Frontiers in medicine
|April 24, 2025
概括
光生物调制 (PBM) 提供了一种通过向口腔微生物群来改善肠道健康的新方法. 这种非侵入性方法也可能通过影响口腔-肠-大脑轴来有益于大脑健康.
科学领域:
- 生物医学科学 生物医学科学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 直接光生物调制 (PBM) 传递到深部胃肠组织是具有挑战性的.
- 口腔微生物组与肠道微生物组密切相关.
- 口腔微生物组的改变可能会影响肠道甚至大脑的健康.
研究的目的:
- 为了探索直接肠道PBM的挑战.
- 通过口腔微生物组的改变,提出一种通过口腔微生物组的改变来间接调节肠道健康的新假设.
- 为了研究神经系统疾病的潜在益处.
主要方法:
- 文献综述和假设的制定.
- 对PBM对口腔微生物群的影响初步研究的分析.
- 探索口腔肠道微生物群轴及其与神经健康的联系.
主要成果:
- 将PBM应用于口腔可以选择性地改变微生物组成.
- 这种口腔变化可能通过口腔-肠道微生物群轴间接影响肠道健康.
- 初步证据表明,PBM诱导的口腔微生物组变化可能会影响神经健康.
结论:
- 口服PBM为治疗肠道疾病提供了一个有前途的非侵入性策略.
- 通过PBM调节口腔微生物群可以为神经疾病提供一种新的治疗途径.
- 进一步的研究对于验证这些发现和了解潜在机制至关重要.
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