分子特征双向地将心肌梗塞和肺癌联系起来
Dhruva Nandi1, Rajiv Janardhanan1, Sridhar Hannenhalli2
1Division of Medical Research, SRM Medical College Hospital & Research Centre, SRMIST, Kattankulathur, Chennai, Tamil Nadu, India.
Frontiers in medicine
|April 24, 2025
概括
研究人员发现了35个常见的基因,将心肌梗塞 (MI) 和肺癌联系起来,揭示了共享的分子通路. 这些基因会影响存活率,并有助于区分心脏病发作患者,为这两种疾病提供了新的治疗点.
科学领域:
- 心血管研究研究心血管研究
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 心肌梗塞 (MI) 和肺癌是全球死亡的主要原因.
- 吸烟和高血压等共同的风险因素将这些不同的疾病联系在一起.
- 识别分子联系对于改善患者的治疗结果至关重要.
研究的目的:
- 为了确定MI和肺癌之间的共同差异表达基因.
- 探索共享的生物过程及其临床影响.
- 为同时发生的心脏病发作和肺癌提出新的治疗策略.
主要方法:
- 在MI,肺腺癌 (LUAD) 和肺状细胞癌 (LUSC) 数据集中的差异基因表达分析.
- 鉴定了35个常见失调的基因.
- 功能丰富分析,Cox比例危险建模,机器学习分类和药物重定向分析.
主要成果:
- 确定了35个在MI,LUAD和LUSC中常见上调或下调的基因.
- 共同的生物过程包括炎症反应和细胞分化.
- 常见的基因与肺癌存活率和吸烟史显著相关.
- 机器学习模型以高准确度区分了心脏病发作患者 (AUROC 0.72,AUPRC 0.86).
结论:
- 在MI和肺癌之间存在共享的分子签名.
- 这些基因为预后和诊断提供了潜在的生物标志物.
- 针对这些基因的药物重新定位为伴随疾病的疾病提供了新的治疗途径.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
66
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
66
02:39lncRNA - Long Non-coding RNAs
8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K