和多基物质暴露与骨矿物质之间的关联:系统性审查和最佳证据综合
Kai Tao1,2, Bin Zeng1,2, Linghui Deng3,4
1Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.
Environment & health (Washington, D.C.)
|April 24, 2025
概括
暴露于某些和多基物质 (PFAS),包括PFOS,PFOA和PFNA,与骨矿物质的减少有关. 性差异可能会影响这些对骨健康的负面影响,需要进一步调查.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 和多醇基物质 (PFAS) 是具有生物累积性质的持久性环境污染物.
- 骨矿物质密度 (BMD) 的降低是骨质疏松症的重要危险因素.
- 了解特定的PFAS对骨健康的影响对于公众健康至关重要.
研究的目的:
- 系统地审查和综合有关常见PFAS (PFOA,PFOS,PFHxS,PFNA,PFDA) 和骨矿物质参数之间的相关性证据.
- 评估PFAS暴露对骨矿物质密度 (BMD),BMDz-score和骨矿物质含量 (BMC) 的影响.
主要方法:
- 在线数据库的系统文献搜索.
- 包括检查特定PFAS和骨矿物质参数之间的关联的研究.
- 进行元分析和最佳证据综合 (BES),以评估证据的强度和一致性.
主要成果:
- 最佳证据综合表明,PFOS,PFOA和PFNA与骨矿物质减少之间存在中度证据.
- 分析显示,PFOA暴露和BMD之间存在负相关性.
- 按性别分类的子组分析显示,PFOS和PFOA暴露与骨硬化之间存在负相关性,这表明性别特异性影响.
结论:
- 本综述表明,暴露于PFOS,PFOA和PFNA与骨矿物之间存在负相关性.
- 性别是PFAS对骨矿物质不利影响的潜在缓解因素.
- 需要进一步的研究,以充分阐明PFAS诱导的骨损伤的机制和程度.
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