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引起的急性肌痛症:一个病例报告
Jiashu Yao1, Ruihuan Ye1, Xihao Mao1
1Department of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Frontiers in psychiatry
|April 24, 2025
概括
对双相情感障碍的治疗可能会导致急性肌神衰竭,这是一个罕见的神经肌肉疾病. 这一案例凸显了在患者出现突然虚弱和跌倒时考虑毒性的重要性.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 是双相情绪障碍的常见情绪稳定剂.
- 诱导的肌痛性肌痛症是一种罕见但严重的不良反应.
- 之前的报道通常描述慢性,轻度症状.
研究的目的:
- 报告一名青少年双相情感障碍患者中出现一次性重复性急性肌肉衰竭的独特病例,该患者接受了治疗.
- 为了区分这种表现与以前记录的诱导的肌痛症.
- 探索对神经肌肉功能影响的潜在机制.
主要方法:
- 一个18岁的女性患有双相情感障碍的病例报告.
- 详细的临床观察复发性肌痛性衰竭发作.
- 诊断工作包括头骨MRI,MSLT,多睡眠学和EEG.
- 在停止使用时评估症状的消失.
主要成果:
- 患者经历了重复的急性肌痛性衰竭,主要症状是跌倒,与使用直接相关.
- 神经学和睡眠研究测试呈阴性,排除了其他原因.
- 肌性症状在停止后消失,在再次挑战时复发,证实了这种联系.
- 这种病例呈现出急性,广泛的症状,与之前报告的慢性,轻度肌痛症不同.
结论:
- 可以在易受影响的个体,特别是青少年中引起急性,严重的肌痛性肌痛症.
- 该机制可能涉及对乙胆受体代谢,神经递质释放和神经肌肉结节稳定性的影响.
- 临床医生应该保持高的怀疑指数诱导的肌衰竭在双相情感患者呈现出无法解释的神经肌肉症状.
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