糖尿病胃肠道疾病的临床研究状态
Xuechun Fan1, Yanyan Wang2, Jingsi Cao1
1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
这项研究回顾了糖尿病胃肠道疾病的临床试验,发现大多数专注于糖尿病胃衰竭与药物干预. 在这些试验的安全评估和后续行动中存在差距.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 临床试验分析
背景情况:
- 糖尿病胃肠道疾病显著影响患者的生活质量,并带来巨大的经济成本.
- 对这些疾病的临床试验缺乏全面的分析,这阻碍了试验设计的改进和发现研究缺陷.
- 本研究提供了过去十年注册和发表的临床试验的范围概述.
研究的目的:
- 进行与糖尿病胃肠道疾病相关的临床试验的范围概述.
- 分析在ClinicalTrials.gov和ChiCTR注册的试验,以及在PubMed.gov发表的高质量的试验.
- 为了确定趋势,共同的方法和在现场改进的领域.
主要方法:
- 搜索了临床试验.gov和ChiCTR数据库,截至2024年6月14日.
- 包括从2014年6月到2024年6月在PubMed上发表的高影响因子 (≥5) 试验.
- 提取并以表格格式呈现试验数据以进行全面分析.
主要成果:
- 大多数研究集中在糖尿病性胃衰竭上,药物干预是研究的最常见的治疗方法.
- 大多数试验采用小样本大小 (≤100名参与者),并采用随机并行受控设计.
- 很大一部分 (69.01%) 使用了各种遮方法,但安全评估和后续行动经常被遗漏.
结论:
- 对糖尿病胃肠道疾病观察到不同的诊断标准.
- 研究主要集中在糖尿病性胃衰竭,表明可能忽视其他胃肠道并发症.
- 研究设计和疗效评估的异质性需要标准化,以产生更强大的证据.
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