证明空气污染与不同类型的出生缺陷之间的相关性:基于分布滞后非线性模型
Wen Sun1, Qingqing Dong2, Yingying Zhang1
1Department of Epidemiology, School of Public Health, Shanxi Medical University, Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental, Taiyuan, Shanxi, China.
Frontiers in public health
|April 24, 2025
概括
怀孕期间暴露于空气污染会显著增加出生缺陷 (BDs) 的风险,特别是先天性心脏缺陷. 有针对性的公共卫生干预措施至关重要,以保护脆弱的孕妇及其胎儿免受有害污染物的影响.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 毒理学 毒理学 毒理学
背景情况:
- 全球生育率下降需要了解出生缺陷 (BD) 的原因.
- 空气污染越来越令人担忧,因为它有可能穿过胎盘屏障.
研究的目的:
- 调查空气污染暴露与胎儿BD风险之间的非线性,滞后的关系.
- 为了确定特定的BDs,怀孕期间的临界暴露期.
主要方法:
- 使用分布式滞后非线性模型 (DLNM) 与来自长市 (2019-2021) 的 BD 数据.
- 分析了来自五个监测站的每小时空气质量数据.
- 与BD流行率相关的每周空气污染物水平.
主要成果:
- 在怀孕早期/中期暴露于SO2,NO2,PM10,PM2.5,O3和CO时,增加了BD风险.
- 特定的污染物显示,在不同的妊娠周,各种缺陷 (例如,心脏病,多动脉,突动脉,唇裂) 的风险高峰相关性.
- PM10,PM2.5和CO与外耳形有关;NOX和NO与突触有关.
结论:
- 产前暴露于空气污染物增加了各种出生缺陷的风险.
- 在第一和第二季度存在关键的脆弱性窗口.
- 建议孕妇采取有针对性的公共卫生策略,以减轻暴露风险.
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