核 accumbens 功能连接性变化 潜在的酒精预期在双相情感障碍和潜在的酒精结果:一个在主体随机的安慰剂控制的酒精管理fMRI研究
Elizabeth T C Lippard1,2,3,4,5, Dylan E Kirsch1,3,4,6, Vanessa Le1,7
1Department of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, United States.
Frontiers in neuroscience
|April 24, 2025
概括
患有双相情感障碍的人从安慰剂中经历了更大的中毒,并显示出大脑连接的改变,这可能预测未来的酒精使用和问题. 这些发现突出了双相情感障碍中独特的安慰剂反应,并提出了潜在的干预目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成研究 研究成研究
背景情况:
- 酒精使用障碍 (AUD) 在双相情感障碍 (BD) 患者中比一般人群更为普遍.
- 对于BD和AUD同时发生的具体机制的了解有限.
- 以前的研究表明,在早期的BD中,酒精预期和安慰剂反应的差异.
研究的目的:
- 调查双相情感障碍的年轻成年人对安慰剂饮料消费的主观和神经反应.
- 为了比较患有BD和健康对照人群之间的安慰剂反应.
- 在BD中探索安慰剂反应,神经连接和未来酒精使用之间的关联.
主要方法:
- 一个受试者内部,安慰剂控制的酒精管理研究,涉及54名年轻成年人 (53%患有BD I型).
- 休息状态功能性MRI (rsfMRI) 扫描在基线和安慰剂/酒精消费后进行.
- 测量了主观的反应,并分析了核突 (NAc) 的功能连接.
主要成果:
- 与健康对照组相比,患有BD的年轻成人在安慰剂条件下报告了更大的中毒.
- 与控制组不同的是,安慰剂的消费导致了BD中NAc与感觉运动网络的连接性增加.
- 较大的安慰剂诱导的抗焦虑效应和NAc连接性与增加的酒精使用和BD的随访问题相关.
结论:
- 在患有双相情感障碍的人群中观察到明显的安慰剂反应,包括独特的神经相关物.
- 这些安慰剂反应差异可能与潜在的酒精使用和问题有关.
- 调查结果表明,针对预期的干预措施有可能解决在BD中同时出现的AUD.
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