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Updated: May 10, 2025

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如何区分N和O:控制甲基转移酶的化学选择性

Emely Jockmann1, Helena Girame2, Wieland Steinchen3,4

  • 1Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104 Freiburg, Germany.

ACS catalysis
|April 24, 2025
PubMed
概括

被称为S-Adenosyl-l-methionine (SAM) -依赖甲基转移酶 (MTs) 的酶通过不同的构造状态来实现特定的化学选择性. 工程设计这些酶改变了它们的甲基转移偏好,揭示了动态控制的选择性.

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