儿科年龄的长期COVID:意大利的一项观察性,前性,纵向性,多中心研究
Susanna Esposito1, Matteo Puntoni2, Michela Deolmi1
1Pediatric Clinic, University Hospital, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Frontiers in immunology
|April 24, 2025
概括
长期COVID (LC) 影响了16.2%的意大利儿童,呼吸系统和神经系统症状是最常见的. 虽然儿科LC比成年人少,但需要有针对性的随访和进一步研究其长期影响.
科学领域:
- 儿童传染病 儿童传染病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 长期COVID (LC) 是一个日益关注的问题,关于其在儿科人口中的流行率和特征的数据有限.
- 了解儿科LC对于开发有效的管理和支持策略至关重要.
研究的目的:
- 研究意大利儿童SARS-CoV-2感染后长期COVID的发生和临床表现.
- 确定与儿科LC相关的常见症状和人口因素.
主要方法:
- 这是一项观察性,前性,纵向性,多中心研究,涉及1129名被诊断患有SARS-CoV-2的儿童.
- 通过感染后1-12个月的问卷收集的数据;LC定义为持续≥2个月的症状,诊断后≥3个月发生.
主要成果:
- 16.2%的儿童经历了长期的COVID,其中68.6%报告至少有一个COVID后症状.
- 最常见的症状:呼吸道 (43.4%),神经/认知 (27.7%),胃肠道 (22.1%),疲劳 (21.6%),睡眠障碍 (18.8%).
- 年龄较大的儿童和女性患心血管和神经/认知功能障碍的患病率较高.
结论:
- 儿科长期COVID呈现与成年人相似,但频率较低,可能是由于儿童的COVID-19疗程较轻.
- 调查结果强调需要针对性地对受影响儿童进行跟踪和支持.
- 对疫苗影响和SARS-CoV-2变种的进一步研究对于儿科LC管理至关重要.
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