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人参及其在非酒精性脂肪肝疾病中的功能成分:治疗效果和多目标药理机制

Ping Xiao¹, Zhaorui Ye¹, Xiuyan Li¹

¹School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in pharmacology

|April 24, 2025

概括

人参显示出治疗非酒精性脂肪性肝病 (NAFLD) 的潜力,通过准多种途径. 这项研究揭示了NAFLD干预的复杂,多组件,多目标机制.

科学领域:

药理学药理学是指药理学的学科.
肝病学肝病学是一种肝病学.
传统中国医药传统中国医药

背景情况:

非酒精性脂肪肝 (NAFLD) 是一个日益严重的全球健康问题,有效的治疗方法有限.
NAFLD的进展与非酒精性脂肪肝炎和肝纤维化有关.
人参 (Panax人参) 是一种具有NAFLD干预潜力的传统药物,但其机制需要进行系统分析.

研究的目的:

系统地审查和阐明人参在治疗NAFLD中的多目标药理机制.
整合过去二十年来广泛研究的证据.

主要方法:

在主要的科学数据库 (PubMed, Web of Science, Embase, CNKI) 进行全面的文献搜索.
对人参的活性成分的分析,包括沙素和非沙素.
使用BioRender和Visio创建的生物医学插图.

主要成果:

人参含有多种活性化合物,包括各种沙素和非沙素.
人参及其成分调节关键的NAFLD途径:脂质代谢,炎症,氧化应激,内分泌网膜应激,胰岛素抵抗,肠道微生物群,细胞死亡和衰老.
证据支持人参在通过这些多方面的行动治疗NAFLD的潜力.

结论:

这项研究介绍了人参在NAFLD治疗中的第一个整合机制,其特点是"多组分,多目标,多途径"的方法.
人参的多层调节能力为NAFLD提供了一种新的治疗策略.
对人参复杂药理的进一步研究可以促进全面的NAFLD治疗开发.

关键词:

人参 (Panax人参) 人参脂质新陈代谢脂质新陈代谢脂肪毒性损伤的伤害多目标药理学机制多目标药理学机制非酒精性脂肪肝疾病 (NAFLD) 是一种非酒精性脂肪肝疾病.

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