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对前体偏头痛和其背后的潜在机制的基于坐标的元分析

Xiaoping Fan¹, Liang Dong², Hui Li²

¹Phase I Clinical Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in neurology

|April 24, 2025

概括

这项研究发现,前体偏头痛 (VM) 患者的insula-operculum区域的灰质体积减少. 需要进一步的研究来确定这些大脑变化是否是VM的原因或结果.

科学领域:

神经成像是一种神经成像.
神经学神经学
神经科学是一个神经科学.

背景情况:

静脉偏头痛 (VM) 是经常出现的常见原因.
基于voxel的形态学 (VBM) 分析大脑灰质 (GM) 体积变化.
缺乏对VM中转基因变化的全面审查.

研究的目的:

系统地审查和元分析VM患者的GM体积的神经成像数据.
在VM中识别特定的大脑区域与改变的GM体积.
评估研究发现的可靠性和一致性.

主要方法:

对多个数据库的系统审查 (PubMed,Embase,科学网,CNKI,万芳).
使用SDM-PSI算法进行基于坐标的元分析 (CBMA).
包括5项研究,包括103名VM患者和107名健康对照 (HC).

主要成果:

与HC患者相比,VM患者观察到的GM体积显著减少.
峰值GM体积减少局限于左侧罗兰 operculum (BA 48),延伸到后面的岛屿.
低异质性 (I2 = 19.35%) 和没有检测到的出版偏差 (埃格尔的测试p = 0.826).

结论:

证实了VM患者后部insula-operculum区域灰质体积的可靠变化.
表明这些结构变化在VM中始终存在.
建议使用标准化方案进行纵向研究,以确定因果关系.

关键词:

基于坐标的元分析.灰色物质是一种灰色物质.岛屿岛屿是一个岛屿.前立腺偏头痛是前立腺偏头痛.基于voxel的形态测量方法

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