在患有类风湿性关节炎的患者中,心表脂肪组织体积和心房动之间的关系
Hao Yao1, Jian Chen1, Xueling Li1
1Heart Center, Department of Cardiovascular Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Frontiers in cardiovascular medicine
|April 24, 2025
概括
患有类风湿性关节炎 (RA) 和心房动 (AF) 的患者表现出心上脂肪组织 (EAT) 体积的增加和EAT与左心房直径之间更强的关联. 这突出了EAT作为RA-AF同时发生的潜在因素.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 副心脏脂肪组织 (EAT) 在心脏炎症中起作用,与心房动 (AF) 和类风湿性关节炎 (RA) 有关.
- 在RA和AF患者中,EAT的特定特征以及与之相关的中风和出血风险,仍然在很大程度上未被描述.
研究的目的:
- 在患有类风湿性关节炎 (RA) 和心房动 (AF) 的患者中研究心表脂肪组织 (EAT) 的体积和特征.
- 评估RA和AF患者中EAT和左心房 (LA) 直径之间的关系.
- 评估RA和AF同时存在的患者中风和出血风险.
主要方法:
- 追溯分析年龄≥18岁的RA和无RA患者,比较EAT体积和EAT/身体质量指数 (BMI) 比率,使用胸部计算机断层扫描.
- 使用CHA2DS2-VASc分数评估中风风险,使用HAS-BLED分数评估出血风险.
- 根据RA状态分层的EAT/BMI比率和LA直径之间的相关性分析.
主要成果:
- 患有AF的患者,无论RA状态如何,与没有AF的患者相比,表现出更大的EAT体积和EAT/BMI比率.
- 在RA患者中,EAT/BMI比率与LA直径有显著的相关性 (RR = 2.23,P < 0.001),但在非RA患者中没有显著的相关性 (P < 0.954).
- 与非RA患者相比,RA患者的LA-EAT体积和LA-EAT/总EAT比率显著增加.
- 与非RA+AF组相比,RA+AF组中风风险得分较高的患者比例在RA+AF组中较高.
结论:
- 左心房直径与RA患者的EAT/BMI比率有关.
- 与没有RA的患者相比,RA患者的LA-EAT体积和LA-EAT/总EAT比率增加.
- 这些发现表明,EAT特征与RA和AF的相互作用之间存在潜在的联系.
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