一系列淋巴细胞疾病在COVID-19疫苗接种后发展
Yukako Umezawa1, Hitoshi Suzuki1, Hitomi Hirose1
1Nephrology, Juntendo University Urayasu Hospital, Urayasu, JPN.
Cureus
|April 24, 2025
概括
COVID-19 mRNA疫苗可能会引发新的或复发的淋巴细胞疾病,如IgA脏病和最小变化疾病. 长期监测对于患有疫苗相关脏问题的患者至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 使者RNA (mRNA) COVID-19疫苗是有效的,但与不良事件相关.
- 报告显示疫苗相关的球细胞疾病,包括IgA脏病 (IgAN) 和最小变化疾病 (MCD).
研究的目的:
- 调查COVID-19 mRNA疫苗接种后的淋巴细胞疾病的临床特征,疫苗类型和结果.
- 在接种疫苗后呈现蛋白尿或血液尿的患者中分析脏活检结果.
主要方法:
- 在mRNACOVID-19疫苗接种后,对30名患有淋巴细胞疾病的患者进行了回顾性分析.
- 评估临床数据,疫苗史,尿液分析和脏活检结果.
- 组织学检查,以诊断特定的淋巴细胞疾病.
主要成果:
- 大多数患者是女性 (63.3%),平均年龄为42.5岁; 73%接受了Pfizer,26.7%接受了Moderna.
- 最常见的诊断是IgA脏病 (IgAN) (20/30患者);其他诊断包括MCD,PGNMID,TAFRO综合征和抗GBM疾病.
- 大型出血症 (83.3%) 和性综合征 (13.3%) 是常见的;4名Igan患者出现复发.
结论:
- COVID-19 mRNA 疫苗接种与新发病和复发的淋巴细胞疾病有关.
- 虽然短期结果似乎有利,但一些患者表现出显著的功能下降和蛋白尿.
- 长期跟踪对于评估疫苗相关的球细胞疾病的预后至关重要.
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