与癌症免疫治疗相关的皮肤毒性
Yosra Vaez-Gharamaleki1, Mohammad Amin Akbarzadeh2, Farhad Jadidi-Niaragh3,4
1Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Toxicology reports
|April 24, 2025
概括
癌症免疫疗法可以改善生存率,但会导致皮肤问题. 本综述详细介绍了管理这些常见的与免疫相关的皮肤毒性,以保持治疗有效性和患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫疗法改变了晚期癌症的治疗方法,显著提高了生存率.
- 与免疫相关的不良事件 (irAEs) 是常见的,皮肤毒性影响近一半的患者.
- 这些皮肤毒性从轻微的皮疹到严重的,危及生命的疾病.
研究的目的:
- 为提供与癌症免疫疗法相关的皮肤毒性的基于证据的审查.
- 详细介绍这些irAEs的发病,临床表现,发病率,分级和管理.
- 强调平衡免疫疗法疗效与积极的皮肤毒性管理的重要性.
主要方法:
- 对免疫疗法诱导的皮肤毒性最近发现的综合文献综述.
- 分析有关病原,临床表现和分级尺度的数据.
- 综合当前的管理策略及其对治疗结果的影响.
主要成果:
- 皮肤毒性涵盖广泛的范围,包括皮疹,,白病的变化,牛皮形和状的喷发,,光敏感性,头发和指甲的变化,史蒂文斯-约翰逊综合征和有毒的表皮亡.
- 有效的管理需要个性化,多学科的方法及时干预.
- 积极管理对于保持免疫疗法的有效性和改善患者的生活质量至关重要.
结论:
- 皮肤毒性是癌症免疫治疗中经常出现的重大挑战.
- 一种平衡的方法,将免疫疗法与皮肤毒性的警管理相结合,是必不可少的.
- 优化患者的治疗结果需要对这些与免疫相关的不良事件进行彻底的了解和主动处理.
更多相关视频
07:08Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
Published on: August 31, 2022
1.6K
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
12.0K
相关概念视频
Tumor Immunotherapy
398
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
398
Skin Cancer
2.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
2.9K
Skin Diseases and Disorders
2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
Cancer Therapies
7.4K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.4K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Cancer Vaccines
238
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
238
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)