Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Design Example: Capacitance Multiplier Circuit01:20

Design Example: Capacitance Multiplier Circuit

614
In integrated circuit technology, a capacitance multiplier is often utilized to produce a larger capacitance value when a small physical capacitance falls short. This is achieved by a circuit that multiplies capacitance values by a factor of up to 1000, such that a 10-pF capacitor can replicate the performance of a 100-nF capacitor.
The circuit illustrated in Figure 1 below incorporates two op-amps, with the first operating as a voltage follower and the second acting as an inverting amplifier.
614
Cascaded Op Amps01:16

Cascaded Op Amps

537
Operational amplifiers (op-amps) are versatile electronic components that can be interconnected in a cascade - one after another in a linear sequence. This cascading is possible due to their infinite input resistance and zero output resistance, allowing them to maintain their input-output relationships even when connected in series.
In a cascaded system, each op-amp is referred to as a stage. The output of one stage drives the input of the subsequent stage. As the input signal passes through...
537
Clipper Circuit01:18

Clipper Circuit

296
A clipper circuit is a fundamental wave-shaping device that harnesses the unique properties of diodes to alter and control waveform characteristics. This technology is widely used in electronic devices, especially in television and radar communication systems, where it enhances waveform modulation in both transmitters and receivers.
The operation of a clipper circuit can be exemplified by analyzing a dual-clipper configuration setup that integrates two ideal diodes, each paired with a biasing...
296
Voltage Doubler Circuit01:23

Voltage Doubler Circuit

397
A voltage doubler circuit integrates two main components: a clamping section and a rectifier section. The clamping section consists of a capacitor (C1) and a diode (D1), whereas the rectifier section is equipped with another diode (D2) and capacitor (C2). This circuit produces an output voltage with twice the amplitude of the sinusoidal input voltage.
397
The Y-to-Delta Circuit01:19

The Y-to-Delta Circuit

380
A balanced wye-to-delta circuit comprises balanced Y-connected voltage sources and delta-connected loads with no neutral line connection.
The initial step in analyzing a wye-to-delta circuit is to assume a positive phase sequence. These phase voltages are then utilized to calculate the line voltages that occur directly across the delta-connected load impedances. Van, Vbn, and Vcn are the phase voltages in wye, and Vab, Vbc, and Vca are the line voltages for a delta circuit. The relation between...
380
RL Circuits01:14

RL Circuits

2.3K
An RL circuit consists of a resistor and an inductor and may have a source of emf connected to it. The inductor in the circuit helps to prevent rapid changes in current, which can be helpful if a steady current is required but the external source has a fluctuating emf. Consider an open RL circuit connected to a source of constant emf. As soon as the circuit is closed, the current begins to increase at a rate that depends only on the value of the inductance in the circuit. The greater the...
2.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

<i>SHANK3</i> mutations disrupt olfactory valence coding across species, with cortical amygdala mechanisms identified in mice.

Science advances·2026
Same author

AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy.

Cell·2026
Same author

Genetically Modified Primate Models for Brain Disorder Research.

Neuroscience bulletin·2025
Same author

Enhanced Fear Memory in Adult Male C57BL/6 Mice Following Low-Dose Isoflurane Exposure During Juvenile Development.

Brain and behavior·2025
Same author

Pupil dilation and behavior as complementary measures of fear response in Mice.

Cognitive neurodynamics·2024
Same author

Protocol for chemogenetic activation of basal ganglia D1-MSNs and behavioral assessments in a primate Parkinson's disease model.

STAR protocols·2024

相关实验视频

Updated: May 10, 2025

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

6.4K

一个人性化的Gs合DREADD用于电路和行为调制.

Qi Zhang1, Ruiqi Wang2, Liang Zhang3

  • 1Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China.

Frontiers in cellular neuroscience
|April 24, 2025
PubMed
概括
此摘要是机器生成的。

研究人员开发了一种人性化的Gs合设计者受体,仅由设计者药物 (DREADD) 激活,hM3Ds. 这种新型的DREADD有效调节神经元刺激性,并显示出治疗帕金森病的前景,为临床使用提供了潜在的更安全的替代方案.

关键词:
D1-MSNs 是一个D1-MSNs.这是一个可怕的恐惧.在Gs信号传输中.模块化调制的方法神经元激活的过程转基因修饰是一种转基因修饰.

更多相关视频

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

28.4K
Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
08:28

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

905

相关实验视频

Last Updated: May 10, 2025

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

6.4K
Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

28.4K
Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
08:28

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

905

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 神经治疗疗法 神经治疗疗法

背景情况:

  • 由设计药物 (DREADDs) 专门激活的设计受体是神经科学研究中的关键工具.
  • 目前的Gs合DREADDs,像rM3Ds一样,来自非人类蛋白质,这给临床转化带来了潜在的免疫性和耐受性问题.
  • 调节神经元刺激性是治疗神经系统疾病的关键.

研究的目的:

  • 开发一个全序列人性化Gs合的DREADD (hM3Ds),以提高临床适用性.
  • 评估hM3Ds在调节神经元活动和减轻帕金森症表型方面的疗效.
  • 评估hM3Ds对潜在治疗干预的安全性.

主要方法:

  • 设计了一个完整的序列人性化Gs合DREADD (hM3Ds).
  • 与rM3Ds相比,描述了hM3Ds的联体响应概况.
  • 在帕金森病小鼠模型中,选择性地在D1中等棘手神经元 (D1-MSNs) 中表达hM3Ds.

主要成果:

  • hM3Ds表现出与现有的rM3Ds相比,一个可比的DREADD连接体响应概况.
  • 在D1-MSN中hM3Ds的选择性表达成功地激活了基底腺直接通路.
  • 在小鼠模型中,hM3Ds治疗显著缓解了帕金森症表型.

结论:

  • 工程化人性化Gs合DREADD (hM3Ds) 是神经科学研究的一个可行和潜在的安全工具.
  • 在包括帕金森病在内的神经系统疾病中,hM3Ds具有显著的治疗潜力.
  • 这种人性化的DREADD推进了DREADD技术的临床翻译.