药用草药中的四级化合物和健康风险评估
Yasmin S Nasr1, Osama El-Sayed Hussein1, Hassan A El-Gammal1
1Agricultural Research Center, Central Laboratory of Residue Analysis of Pesticides and Heavy Metals in Food (QCAP), Ministry of Agriculture and Land Reclamation, Giza, Egypt.
Food additives & contaminants. Part B, Surveillance
|April 24, 2025
概括
在药用草药中检测到四次性化合物 (QAC). 虽然初步风险评估表明可接受的饮食暴露,但33%的市场样品超过了残留物限值,突出了潜在的担忧.
科学领域:
- 食品化学 食品化学
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 全球对药草的需求正在上升.
- 人们对草药中四级化合物 (QAC) 的健康风险存在担忧,特别是在婴儿身上.
- 在某些涉及草药消费的文化实践中,QACs通常被使用.
研究的目的:
- 开发和验证一种分析方法,用于检测干药草中的五种QAC.
- 为了对商用药草中的QAC进行市场调查.
- 评估不同年龄组中药草中QACs相关的饮食暴露风险.
主要方法:
- 开发用于QAC检测的LC-ESI-MS/MS方法.
- 使用QuEChERS提取用乙尼和一个孔C18列进行分离.
- 方法验证遵循Eurachem和SANTE/11312/2021指南,确保高灵敏度和选择性.
主要成果:
- 经过验证的方法显示出高灵敏度和选择性,恢复率在70-110%之间,相对标准偏差 (RSD) 低于5%.
- 对市场样本的分析显示,33%的QACs超出了确定的最大残留物限值.
- 预先的风险评估表明,成人,幼儿和婴儿的饮食暴露水平是可以接受的.
结论:
- 开发的LC-ESI-MS/MS方法适用于药草中QAC的监测.
- 很大一部分药用草本样本超过了QACs的监管限制.
- 尽管一些样本超出了标准,但目前通过饮食暴露于来自药草的QAC似乎存在可以接受的风险.
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