由颗粒细胞殖民地刺激因子引发的风炎
Andreas Gaustad1, Marthe Halsan Liff2, Aleksander Nordberg Nørgaard3
1Medisinsk avdeling, Diakonhjemmet sykehus, Oslo.
概括
颗粒细胞殖民地刺激因子 (G-CSF) 在淋巴瘤患者中可引起大关节炎,呈发烧和CRP升高的形式. 停止G-CSF和使用成像是诊断和治疗的关键.
科学领域:
- 在瘤学瘤学.
- 血管医学 血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 一名60岁的男性被诊断出患有扩散性大B细胞淋巴瘤.
- 患者在用G-CSF进行化学治疗后出现发烧,肌痛和昏迷.
研究的目的:
- 报告一种罕见的G-CSF诱导的风炎病例.
- 为了突出发烧后G-CSF治疗的诊断考虑.
主要方法:
- 临床病例的介绍.
- 实验室调查,包括对C反应蛋白 (CRP) 的监测.
- 计算机断层扫描 (CT) 扫描用于成像.
主要成果:
- 尽管接受了抗生素治疗,但患者发烧和CRP升高.
- 脑电图扫描显示出主动脉炎,怀疑是G-CSF诱导的.
- 停止使用G-CSF并开始服用普雷迪尼索隆导致了快速改善.
结论:
- 由G-CSF引起的风炎是患有发烧后G-CSF治疗对抗生素无反应的患者的潜在诊断.
- 先进的成像对于诊断至关重要.
- 迅速停止G-CSF是主要的管理策略.
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