西尼罗病毒冠状腺炎:土耳其首例眼部感染病例
Özlem Özkan1, Anıl Akdeniz1, Ziya Ayhan1
1Dokuz Eylül University Faculty of Medicine, Department of Ophthalmology, İzmir, Türkiye.
Turkish journal of ophthalmology
|April 24, 2025
概括
西尼罗病毒 (WNV) 胆红蛋白病变可能导致发烧性疾病后严重的视力丧失. 早期诊断和治疗,如内拉尼比祖马布,可以改善视力敏度,减少视网膜病变.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 西尼罗河病毒 (WNV) 是一种蚊子传播的黄病毒,可引起神经疾病.
- WNV感染的眼部表现,如胆红蛋白病变,很少见,但可能导致显著的视力损伤.
研究的目的:
- 报告双边WNV胆红素病变的病例,呈现严重视力损失.
- 要突出临床特征,诊断方法和WNV胆红蛋白病变的治疗结果.
主要方法:
- 一名患有急性视力损失的59岁男子接受了全面的眼科检查,包括眼底镜和自光成像.
- 系统评估包括WNV聚合酶链反应和血清学测试 (IgM和IgG抗体).
- 进行了脑部MRI,以排除中枢神经系统的参与. 用内拉尼比祖马布治疗黄斑水.
主要成果:
- 患者在右眼出现了严重的视力损失和特征性 fundus 病变,包括类似轨道的超自发光线.
- 检测到WNV IgM和IgG抗体,证实了双边WNV胆红蛋白病变.
- 在治疗后,视觉敏度得到改善,超自流性病变消失,尽管受影响的眼睛仍然存在视觉盘白.
结论:
- 临床医生应考虑在具有特征性 fundus 发现和发烧性疾病病史的患者中考虑 WNV 胆色素变异症.
- 及时诊断和适当的治疗可以导致WNV胆红素病变的良好视觉结果.
相关概念视频
Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Arboviral Encephalitis
70
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
70
Encephalitis l: Introduction
27
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
27
Encephalitis ll: Pathophysiology
30
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
30


