培养负的亚急性乳杆菌内心炎通过微生物无细胞DNA测序来诊断
Abduljabar Adi1, Sandrine Lebrun1, Maiko Kondo2
1Department of Cardiology, Lenox Hill Hospital, New York, New York, USA.
JACC. Case reports
|April 24, 2025
概括
乳酸菌内心炎是一种罕见但严重的感染. 益生菌的使用可能是感染的来源,特别是在术后患者,突出需要先进的诊断.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 心脏病学 心脏病学
背景情况:
- 乳酸菌内心炎是一种罕见的感染,通常在免疫功能低下的个体或具有先前存在心脏病的个体中发现.
- 虽然通常是共生的,但乳酸菌种可以引起侵入性感染.
研究的目的:
- 报告一个Lactobacillus内心炎病例.
- 要突出益生菌使用作为感染源的作用.
- 强调先进的基因检测在诊断罕见感染中的有用性.
主要方法:
- 一个74岁的心脏手术后患者的案例介绍.
- 过食道回声心脏学检测植被.
- 由于阴性血液培养,用于病原体鉴定的元基因组测序.
主要成果:
- 发现了暗示内心炎的植被.
- 通过遗传检测,乳酸菌发酵素被确定为致病原体.
- 患者报告了每天的益生菌消费,被确定为可能的来源.
结论:
- 益生菌应该被视为潜在的来源的细菌病在术后的患者与消极培养.
- 甲基因组测序对于在复杂情况下识别病原体很有价值.
- 及时诊断和适当的抗生素治疗 (安西林) 导致症状消失.
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