在超过7万无症状个体中冠状动脉化分布和进展:对评估间隔和最佳测试年龄的影响
Da-Eun Sung1, Mi-Yeon Lee2, Jong-Young Lee3
1Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
European heart journal. Cardiovascular Imaging
|April 24, 2025
概括
大多数无症状成年人的冠状动脉 (CAC) 评分为零,表明动脉样硬化程度低. 显著的CAC (>100) 是罕见的,在10年后仅在4%的人中存在,即使在老年人中也是如此.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 流行病学 流行病学
背景情况:
- 亚临床动脉样硬化,以冠状动脉 (CAC) 评分为指标,是心血管事件的关键预测因素.
- 了解无症状个体中CAC的进展对于风险分层和预防策略至关重要.
研究的目的:
- 为了确定冠状动脉 (CAC) 在无症状成年人的大量队列中的患病率和进展.
- 为了评估CAC分数为0在这个人群中持续时间的持续时间.
主要方法:
- 对来自韩国30岁以上的70389名无症状个人进行了回顾性分析,在2010年至2022年期间至少进行了两次CAC评分评估.
- 基于随访间隔的子组分析 (整个队列,>=10年内4次评估,5年后的随访).
- 评估特定于年龄和性别的CAC分布,新的CAC发生率,以及6-12年内CAC得分的变化,对于初始得分为0.0的人来说.
主要成果:
- 84%的参与者 (平均年龄为40.5岁,87%的男性) 的基线CAC得分为0;93%的女性的基线CAC得分为0.
- 事件CAC发生在16%的那些在5-6年内初始分数为0的患者中,只有1%的患者超过100分.
- 10年后,只有4%的队列超过了100的CAC得分,这表明显著化的流行率很低.
结论:
- 在无症状的成年人中,基线CAC得分为0是常见的,这意味着最小的亚临床动脉样硬化.
- 显著的冠状动脉化 (CAC>100) 发展缓慢,即使经过十年的随访,很少有个体超过了这一门.
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