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Updated: May 8, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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新型III类抗剂的合理分子设计,以竞争性地破坏人类的PPARδ自我结合

Yue Peng1, Zilong Li1, Yunyi Zhang1

  • 1Center for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China (UESTC), No.2006 Xiyuan Ave, West Hi-Tech Zone, Chengdu, 611731, China.

Journal of computer-aided molecular design
|April 24, 2025
PubMed
概括

研究人员开发了新的III类抗剂,向人类氧酶增殖器激活受体-δ (PPARδ). 这些接通过准H12结合部位来破坏PPARδ激活,提供了一条新的治疗途径.

关键词:
第三类抗剂的对手.计算型类学是指计算型类学.过氧体增殖器激活的受体-δδ.理性的设计理性的设计.自结合的自结合.

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