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囊胚的形态参数用于预测胚胎质量:系统性审查和元分析

Lingying Zhang^1,2, Chengyu Li¹, Na Zhu¹

¹Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science & Technology, Xinjiang University, Urumuqi, 830046, Xinjiang, China.

Journal of assisted reproduction and genetics

|April 24, 2025

概括

这一元分析对辅助生殖技术 (ART) 中活产的胚胎细胞组件进行了排名. 对于成功的胚胎转移结果,体质量 (TE) 和内细胞质量 (ICM) 的质量比囊胚扩张 (EH) 更为关键.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
生物统计学生物统计学

背景情况:

胚胎细胞质量的形态评估对于辅助生殖技术 (ART) 的成功至关重要.
胚胎囊扩张 (EH),内细胞质量 (ICM) 和皮 (TE) 对活产率的相对重要性仍在争论中.
标准化的分级系统,如加德纳分数,用于评估胚胎细胞形态.

研究的目的:

为了比较和排名胚胎细胞组分分类 (EH,ICM,TE) 对活产率的影响.
为在ART中选择高质量的胚胎提供基于证据的指导.
解决关于不同胚胎细胞形态特征的预测价值的争议.

主要方法:

在主要数据库 (CINAHL,Cochrane,Embase,MEDLINE,PubMed,Scopus,中医药) 进行系统的文献搜索,截至2023年2月.
33项研究的元分析,包括42,974个ART胚胎和46,099名女性.
包括报告新生儿结局的研究和EG,ICM和TE的最终加德纳分级.

主要成果:

托菲克托德 (TE) 等级"A"和内部细胞质量 (ICM) 等级"A"与最高的活产率有关.
胚胎囊扩张 (EH) 级别'5'比较有利,但影响力低于TE和ICM质量.
活产儿最有利的形态包括5AA,4AA,6AA,5AB,3AA,5BA,4AB,2AA和4BA.

结论:

囊胚组件的形态评估,特别是TE和ICM,是选择具有更高活产潜力的胚胎的重要工具.
这项研究提供了囊胚细胞形态的排名,以指导ART的临床决策.
根据详细的形态分级优化胚胎选择可以提高ART成功率.

关键词:

辅助生殖技术 (ART) 是一种助孕技术.胚胎质量质量胚胎质量活生生的出生活生生的出生形态学评估形态学评估

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