在自闭症谱系障碍中,突出和默认模式网络之间的过度连接预测了非典型的社会行为
Alina Minnigulova1, Maria Protopova2, Olga Dragoy2,3
1Center for Language and Brain, HSE University, Moscow, Russia. alinaminnigulovahouse@gmail.com.
Journal of autism and developmental disorders
|April 24, 2025
概括
患有自闭症谱系障碍 (ASD) 的人在默认模式网络 (DMN) 和突出网络 (SN) 中显示出改变的连接性. 这些差异会影响自闭症患者的社会反应能力和大脑发育.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 自闭症研究 自闭症研究
背景情况:
- 默认模式网络 (DMN) 和突出网络 (SN) 对社会行为和注意力调节至关重要.
- 这些网络的改变功能和发展被怀疑是自闭症谱系障碍 (ASD),但具体的互动变化和与年龄相关的成熟模式仍然不清楚.
研究的目的:
- 研究与对照组相比,ASD患者的DMN和SN之间的功能连接 (FC) 差异.
- 探索DMN-SN互动性与自闭症特征之间的关系,包括社会反应能力,执行功能和沟通技巧.
- 检查年龄如何影响这些网络在自闭症和典型发育个体中的成熟.
主要方法:
- 从自闭症脑成像数据交换 (ABIDE) 数据集中分析休息状态功能连接 (FC) 数据.
- 在ASD (n=144) 和健康对照 (n=99) 个体中,DMN和SN内部和之间FC的比较.
- 在ASD组中,评估FC与行为指标 (社会反应能力,执行功能,适应性行为) 之间的相关性,以及与年龄相关的对FC的影响.
主要成果:
- 与对照人群相比,患有自闭症的个体在DMN和SN之间增加了FC,同时在DMN内减少了FC.
- 右岛内皮层和中部前额皮层之间的功能连接与ASD中更大的社会反应障碍有关.
- 在ASD中DMN和SN的成熟模式与在典型发育中观察到的部分不同.
结论:
- 这些发现揭示了ASD患者的DMN和SN内部和之间本质功能连接的显著差异.
- 改变的DMN-SN相互作用有助于特定的自闭症特征,特别是社会反应障碍.
- 这些结果强调了研究DMN和SN发展和ASD互动性的重要性,以全面了解这种疾病.
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