肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强 肌肉增强
Aline Alves de Souza1,2, Stephano Tomaz da Silva1,2, Amanda Mayra Pereira Régis1,2
1Department of Physical Therapy, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
PloS one
|April 24, 2025
概括
与常规护理相比,肌肉强化炼对肌缩性侧面硬化症 (ALS) 患者没有短期益处. 需要更严格的研究来确认ALS康复的有效性和长期影响.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 运动科学 运动科学
背景情况:
- 正确规定的炼对患有骨髓缩侧面硬化症 (ALS) 的个体有好处.
- 关于肌肉强化炼对ALS的影响,研究有限,缺乏共识.
- 这会影响患者的康复策略.
研究的目的:
- 系统地评估肌肉强化干预措施对ALS患者的影响.
- 将肌肉强化干预与非强化干预,常规护理或安慰剂进行比较.
- 评估对外围肌肉强度,功能,疲劳和不良事件的影响.
主要方法:
- 对干预研究和临床试验的系统审查.
- 在2023年10月在多个数据库 (MEDLINE,EMBASE,Cochrane图书馆,SPORTDiscus,PEDro) 进行的搜索.
- 包括的研究集中在ALS患者的非呼吸肌肉强化.
- 使用PEDro尺度评估偏差风险;用GRADE评估证据质量.
主要成果:
- 包括8项研究,共计296名个人.
- 七项研究表明实验干预的优越性,但元分析没有支持这一点.
- 在短期内,肌肉强化和控制干预措施之间没有发现显著差异.
- 证据质量始终低至非常低,归因于样本规模小和异质性高.
- 在评估这些严重不良事件的五项研究中,没有报告任何严重不良事件.
结论:
- 肌肉强化干预措施在短期内对ALS患者没有显示出对照组的优势.
- 目前的证据质量很低,这凸显了对方法严格研究的需要.
- 需要进一步的研究来最终评估肌肉增强对ALS的短期,中期和长期影响.
更多相关视频
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
12.5K
08:16Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
Published on: March 4, 2014
31.5K
相关概念视频
Exercise and Muscle Performance
1.2K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.2K
Myasthenia Gravis: Overview and Treatment
958
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
958
Cross-bridge Cycle
115.8K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
115.8K
Disorders of the Skeletal Muscle
826
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
826
Myasthenia Gravis: Diagnostic Tests
538
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
538
