牛乳杆菌 johnsonii JERA01激活巨细胞,并增加了小肠小肠小鼠的Th-1 T细胞数量
So Yeon Ahn1, Hong-Gu Joo1, Eun-Ju Ko1
1College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, Republic of Korea.
PloS one
|April 24, 2025
概括
被热杀死的 Lactobacillus johnsonii (LJ) 激活了巨细胞和树突细胞等免疫细胞. 这种细菌刺激T细胞的增加,表明其作为免疫增强补充剂的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 牛乳杆菌 johnsonii是一种肠道和阴道开始性细菌.
- 它以潜在的抗炎作用和增强上皮屏障而闻名.
- 以前的研究集中在它的抗炎性质上.
研究的目的:
- 为了研究热杀死 Lactobacillus johnsonii JERA01 (LJ) 的免疫刺激作用.
- 检查LJ对小鼠抗原呈现细胞和T细胞群的影响.
主要方法:
- 给小鼠补充了热杀死的LJ.
- 骨髓衍生的树突细胞 (BMDCs) 和巨细胞 (BMDMs) 用LJ进行了预处理.
- 进行了对淋巴细胞的共同培养实验.
- 分析了腹腔腔和皮耶斑块中的巨细胞透和T细胞种群.
主要成果:
- 在BMDCs和BMDMs中,LJ预治疗增加了成熟标志物和细胞因子生产 (TNF-α,IL-6,IL-12p40).
- 与LJ预处理细胞共同培养增强了IFN-γ的产生.
- 口服LJ给药导致巨细胞透,并增加了皮耶补丁中的IFN-γ产生T细胞.
结论:
- 被热杀死的L. johnsonii激活了巨细胞和树突细胞.
- 补充LJ可以增加肠道中的Th-1 T细胞群.
- L. johnsonii 显示出作为免疫刺激剂的潜力.
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