怀孕期间的心脏生物标志物,有或没有高血压
Lara C Kovell1,2, Mawulorm K I Denu1, Julia Berkowitz1
1Division of Cardiovascular Medicine, Department of Medicine, UMass Chan Medical School, Worcester, MA.
American journal of hypertension
|April 24, 2025
概括
怀孕期间的高血压与心脏损伤标志物有关. 在所有孕妇中,分娩会增加压力和炎症标志物,无论高血压状况如何.
科学领域:
- 心血管医学 心血管医学
- 产科 产科 产科 产科 产科
- 生物标志物研究 生物标志物研究
背景情况:
- 妊娠高血压 (HTN) 损伤的机制尚不清楚.
- 这项研究调查了怀孕中HTN和没有HTN的心脏损伤,应变和炎症标志物.
研究的目的:
- 检查心脏损伤 (hs-cTnI),应变 (NT-proBNP) 和炎症 (hs-CRP) 标志物的趋势.
- 为了比较这些标记在怀孕和没有HTN的孕妇之间.
主要方法:
- 孕妇 (24-32周怀孕) 的前性1:1病例对照研究 (2019-2022年).
- 根据临床诊断或血压≥140/90 mmHg定义的HTN.
- 在基线,分娩前和分娩后1天收集的血清样本;使用混合效应的托比特模型进行分析.
主要成果:
- 与非HTN组相比,HTN组的hs-cTnI水平较高 (2.12对1.07ng/L).
- 这两组从基线到产后都出现了hs-cTnI的增加.
- 在两组之间,NT-proBNP和hs-CRP水平相似,但从基线到产后显著增加.
结论:
- 怀孕高血压与心脏损伤标志物升高有关.
- 产后本身增加了心脏应变和炎症的标志物.
- 生物标志物的变化可以阐明HTN怀孕中不良心血管事件背后的机制.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
37
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
37
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
66
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
66
Hormonal Regulation
32.7K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.7K
Hypertension and Regulation of Blood Pressure
1.8K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.8K
Errors occurring during blood pressure monitoring
565
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
Several factors...
565
Adrenergic Antagonists: ɑ and β-Receptor Blockers
379
Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is...
379


