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微型空气污染暴露的来源和成分以及青春期前青少年的大脑形态

Kirthana Sukumaran¹, Katherine L Bottenhorn², Michael A Rosario¹

¹Department of Population and Public Health Sciences, University of Southern California, 1845 N. Soto St, Los Angeles, CA 90089, USA.

The Science of the total environment

|April 24, 2025

概括

空气污染,包括细颗粒物 (PM2.5) 和二氧化 (NO2),影响儿童的大脑发育. 不同的PM2.5来源,如生物质燃烧和交通,与特定的大脑结构变化有关.

科学领域:

神经科学是一个神经科学.
环境健康环境健康
儿科儿科儿科

背景情况:

空气污染是儿童和青少年新兴的神经毒剂.
人们对细颗粒物 (PM2.5) 的成分和来源如何影响大脑形态的理解有限.
儿童和青少年大脑发育是环境暴露的关键时期.

研究的目的:

研究空气污染暴露与儿童大脑形态之间的关联.
检查PM2.5成分和来源对大脑结构的影响.
确定与大脑发育不同影响相关的特定空气污染源.

主要方法:

在青少年大脑认知发展研究中利用了10,095名儿童 (9-11岁) 的横截面磁共振成像数据.
对PM2.5成分,主要PM2.5来源 (如生物质燃烧,交通),二氧化 (NO2) 和臭氧 (O3) 的评估暴露.
采用了部分最小平方分析来将共同暴露与皮层厚度,表面积和皮层下体积联系起来,并调整为共变量.

主要成果:

对PM2.5和NO2的更大暴露与前额表面积的减少和下面积的增加有关.
PM2.5的组成部分和来源 (生物质燃烧,地物质,交通) 与皮质表面积和厚度有关.
特定的暴露,如,与较小的皮下体积有关.
在支持认知和社会情绪功能的大脑结构中发现了显著的关联.

结论:

这项研究是首次证明各种空气污染源对儿童大脑结构的差异性影响.
空气污染暴露,特别是生物质燃烧,地材料和交通,与大脑形态的特定变化有关.
研究结果强调了空气污染对青春期前儿童的神经发育的风险,并强调了确定特定污染源的重要性.

关键词:

青少年时期青春期磁共振成像技术磁共振成像技术神经发育神经发育神经毒剂是一种神经毒剂.颗粒物质颗粒物质是什么来源分配的分配方式

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