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Updated: Jul 15, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

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黄粉虫虫 (Tenebrio molitor) 幼虫作为抗莱什曼药物评估的替代模型

Michel Muálem de Moraes Alves1, Victoria Hannah Araújo de Almeida Passos1, Paulline Paiva Mendes de Souza Leal1

  • 1Graduate Program in Technologies Applied to Animals of Regional Interest, Federal University of Piauí, Teresina, PI, Brazil; BioLeish-Advanced Research in Leishmania and Alternative Models, Medicinal Plants research Center, Federal University of Piauí, Teresina, PI, Brazil.

Veterinary parasitology
|April 24, 2025
PubMed
概括

黄粉幼虫为研究莱什曼病提供了一个有希望的替代模型. 这种无脊椎动物模型模仿宿主反应,有助于开发新的抗莱什曼病药物.

关键词:
替代方法 替代方法无脊椎动物是一种无脊椎动物.莱什曼病是一种莱什曼病.梅拉尼化的过程有毒性 有毒性

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In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice06:57

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Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...