在一项大型纵向研究中减轻空气污染对肺癌的影响:饮食干预措施的未开发潜力
Yong-Sheng Yang1, Xu-Wei Tang1, Ji-Fu Wu1
1Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian 350122, China.
Ecotoxicology and environmental safety
|April 24, 2025
概括
长期暴露于空气污染会显著增加肺癌的风险. 饮食不良与空气污染相结合,协同提高了这种风险,突出了需要公共卫生干预的必要性.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 肺癌是全球主要的健康问题,环境和生活方式因素起着重要作用.
- 关于多种空气污染物的影响及其与饮食对肺癌风险的联合影响的证据有限.
研究的目的:
- 调查暴露于混合空气污染物和肺癌风险之间的关联.
- 评估饮食模式对肺癌风险的影响.
- 研究空气污染和饮食对肺癌的协同作用.
主要方法:
- 利用了来自327,147名参与者的英国生物库数据.
- 使用加权回归系数评估多种空气污染物 (PM10,PM2.5,NO2,NOx,SO2) 的暴露.
- 使用健康饮食评分测量饮食质量,使用Cox比例危险模型分析肺癌风险.
主要成果:
- 对空气污染物的更高暴露与肺癌风险增加有显著关联 (HR: 1.41).
- 像PM2.5 (HR: 1.50) 和NO2 (HR: 1.35) 这样的单个污染物显示出了显著的关联.
- 健康饮食与肺癌风险降低有关 (HR:0.88),而与空气污染相结合的不健康饮食显示出协同风险升高 (协同指数:1.40).
结论:
- 糟糕的饮食习惯放大了空气污染对肺癌风险的有害影响.
- 公共卫生战略应集中在减少空气污染和促进更健康的饮食,以预防肺癌.
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