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从成像诊断的肺栓塞的长期死亡率在女性和男性
Eitan Sosner1, Bertin Mathai2, Abraham Bordon2
1Montefiore Medical Center, United States of America.
Clinical imaging
|April 24, 2025
概括
肺栓塞 (PE) 对女性的死亡风险比男性高,即使考虑到年龄和健康状况. 这项研究突出了PE结果中的显著性别差异.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 肺栓塞 (PE) 是一种严重的疾病,其严重程度和风险因素因性别,年龄和并发症而有所不同.
- 了解PE患者基于性别的长期死亡率差异对于有效的风险分层和管理至关重要.
研究的目的:
- 调查和比较诊断为PE的男性和女性的一年死亡率.
- 分析性别对PE相关死亡率的影响,根据年龄和并发症状况进行调整.
主要方法:
- 在7年内,对33,628名通过V/Q光阴图或CT肺血管图诊断出PE的成年患者进行了回顾性分析.
- 电子健康记录被用来收集患者数据,包括查尔森并发症指数 (CCI).
- 使用EHR和国家死亡指数来确定一年死亡率,并使用Cox比例危险模型进行分析.
主要成果:
- 对于PE队列的整体一年死亡率为女性9.9%,男性为16.8%.
- 与男性 (HR 1.38) 相比,患有PE的女性的死亡风险比率显著更高 (HR 2.75).
- 在调整了年龄和CCI后,女性仍然显示出比男性 (HR 1.20) 高的危险比率 (HR 1.68),导致相似的一年死亡率 (21.9%对21.5%).
结论:
- 诊断PE与显著增加的一年死亡率有关,在女性中观察到的效果明显更强.
- 在PE对死亡率的影响中,这种性别差异在控制年龄和并发症后仍然存在.
- 对驱动PE中这些性别特异性结果的潜在机制进行进一步的研究是有必要的.
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