在患有牙周病的患者中,中风后认知障碍的决定因素
Karly Pikel1, Lawson Logue1, Haley Verkuilen1
1Department of Neurology, University of South Carolina School of Medicine and Prisma Health Midlands, 1 Medical Park Suite 230, Columbia, SC 29203, USA.
概括
牙周病 (PD) 是中风后认知障碍 (PSCI) 的新型预测因素. 严重的PD独立地导致早期PSCI,以及种族和中风严重程度,而教育提供了保护.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 口腔健康 口腔健康
背景情况:
- 牙周病 (PD) 是已知的中风和心血管疾病的风险因素.
- 病发症对中风后认知障碍 (PSCI) 的影响尚不清楚.
- 大脑小血管疾病 (cSVD) 是中风患者的常见发现.
研究的目的:
- 调查牙周病严重程度与中风后认知障碍之间的关联.
- 为了确定早期PSCI的新风险因素.
- 评估cSVD在PSCI中的作用.
主要方法:
- 从PREMIERS研究中对280名参与者的横截面分析.
- 在中风后90天内使用蒙特利尔认知评估 (MoCA) 评估认知功能.
- 后勤回归和通用线性混合建模用于分析MoCA得分和临床数据,包括对cSVD的Fazekas尺度.
主要成果:
- 48%的患有PD的参与者经历了严重的PSCI.
- 严重的PD,非裔美国人种族,以及更严重的中风严重程度是严重PSCI的显著独立预测因素.
- 研究发现,高等教育对PSCI有保护作用. 在cSVD和PSCI之间没有发现显著的关联.
结论:
- 牙周病的严重程度是早期中风后认知障碍的新和独立因素.
- 传统的风险因素,包括种族和中风严重程度,仍然是PSCI的重要预测因素.
- 需要进一步的研究来探索PD和PSCI之间的联系机制.
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