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怀孕期间的SARS-CoV2疫苗接种 - 检查对母亲健康的影响以及对后代大脑功能的长期后果

Anna Gundacker¹, Ron Schaer², Arnold Pollak³

¹Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Brain, behavior, and immunity

|April 24, 2025

概括

在怀孕期间接种COVID-19疫苗是安全的. 一项小鼠研究没有发现对母亲健康,妊娠结果或后代神经发育的不良影响,消除了关于疫苗诱导疾病的迷思.

科学领域:

免疫学免疫学免疫学
神经科学是一个神经科学.
生殖健康生殖健康

背景情况:

对于孕妇来说,COVID-19疫苗接种至关重要,但由于对神经精神病风险的毫无根据的担忧,犹仍然存在.
临床前模型对于评估妊娠期间疫苗安全性至关重要.

研究的目的:

评估妊娠期被动免疫接种SARS-CoV-2中和单克隆抗体 (SaCoV-AB) 对怀孕结果,母亲健康和后代神经行为的影响.
调查母体COVID-19抗体暴露与后代神经发育障碍之间的潜在联系.

主要方法:

在怀孕期间利用小鼠模型进行SaCoV-AB的被动免疫接种.
监测怀孕结果,孕产妇免疫反应 (TNF-α水平) 和产后孕产妇护理.
对子女进行了神经发育现象型的行为评估.

主要成果:

在较高的SaCoV-AB剂量下观察到增加的母体血清TNF-α,而不会影响胎盘或胎儿大脑.
没有对怀孕结果,产妇护理或新生儿沟通的不良影响.
后代在成年时表现出正常的神经行为现象型,没有神经发育障碍的迹象.

结论:

在临床前的模型中,SaCoV-AB的孕期被动免疫接种被很好地容忍.
该研究没有发现证据支持疫苗与后代相关的神经精神疾病风险的担忧.
这些发现支持怀孕期间COVID-19抗体暴露的安全性.

关键词:

细胞因子 (cytokines) 是一种细胞因子.孕期疫苗接种妊娠疫苗接种母亲的行为母亲的行为被动免疫接种是一种被动免疫接种.严重急性呼吸系统综合征冠状病毒2 超声波发声的发声方式

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