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在食品安全中对脱酸盐进行网络毒理分析

Jing Jin¹, Yan Xue², Liang Tian¹

¹Center for Rehabilitation Medicine, Department of Rehabilitation, Neurotumor Rehabilitation Ward, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|April 24, 2025

概括

脱乙酸盐 (Na-DHA) 具有多器官毒性风险,包括基因毒性和肝毒性. 网络毒理学揭示了共享的分子途径,突出了超越单一终点的综合风险评估的需要.

科学领域:

毒理学毒理学毒理学
网络生物学网络生物学
计算化学的计算化学

背景情况:

脱酸 (Na-DHA) 是一种合成防腐剂,面临着越来越严格的监管审查.
评估其多器官毒性潜力对于公共健康和安全至关重要.
网络毒理学提供了一个系统层面的方法来理解复杂的化学诱导病理.

研究的目的:

通过网络毒理学研究脱乙酸盐 (Na-DHA) 的多器官毒性.
预测潜在的风险,包括基因毒性,肝毒性和致癌性.
确定关键的分子标和涉及Na-DHA诱导毒性的途径.

主要方法:

使用ADMETlab3.0进行毒性预测.
执行目标挖掘以确定与癌症,肝损伤和基因毒性相关的核心基因.
进行功能和KEGG通路分析以阐明潜在的机制.
综合网络分析,以评估类效应和共享途径.

主要成果:

ADMETlab3.0预测了基因毒性,肝毒性和致癌性的重大风险.
在不同的毒理终点中识别了共享的核心基因 (ALOX5,PTGS2,SMAD3,TNF).
揭示了炎症,氧化应激和免疫失调作为中心机制.
癌症/肝脏损伤与AGE-RAGE信号传递和基因毒性与血细胞衰竭有关,这表明DNA修复中断.

结论:

脱乙酸 (Na-DHA) 通过融合途径介导的类效应,影响多个器官.
鉴定的分子机制挑战了传统的单一终点毒性评估.
建议采用全面的多器官风险评估方法进行Na-DHA的监管评估.

关键词:

食品添加剂是一种食品添加剂.食品安全食品安全网络毒理分析网络毒理分析脱乙酸盐的使用方法

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