休息状态连接的任务相关变化受到时间干扰 (TI) 刺激的影响.
Danielle Lauren Kurtin1, Ketevan Alania1, Edward Rhodes1
1Division of Brain Sciences, Imperial College London, London, UK; UK Dementia Research Institute, Imperial College London, London, UK.
Brain stimulation
|April 24, 2025
概括
非侵入性脑刺激可以在记忆任务后改变大脑网络活动. hippocampus 的时间干扰 (TI) 刺激 敏度调节 功能连接 (FC) 从先前的记忆任务的痕迹.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 脑部成像 脑部成像
背景情况:
- 休息状态的大脑网络活动和功能连接 (FC) 受先前的认知任务的影响,比如记忆形成.
- 大脑刺激技术可以改变静止状态的大脑活动和FC.
- 目前尚不清楚大脑刺激是否能急性地改变认知任务对大脑活动或FC的残留影响.
研究的目的:
- 调查海马的非侵入性时间干扰 (TI) 刺激是否可以调节海马休息状态的 FC 痕迹,这些痕迹是由之前的海马依赖任务留下的.
主要方法:
- 20名健康参与者在关联记忆任务之前和之后接受了休息状态功能磁共振成像 (rsfMRI).
- 在任务后的休息状态中,对海马进行了theta带TI刺激或假刺激.
- 双向相互信息功能连接 (miFC) 通过 permutation 测试进行了分析,以比较任务前和任务后的状态以及 TI 刺激的影响.
主要成果:
- 与任务前基线相比,任务后假刺激在几个网络中显示出显著较低的miFC,包括前 (AT) 和后 (PM) 网络,与任务前基线相比.
- 在任务后的休息状态中,海马体的TI刺激增加了海马体AT和PM网络以及其他功能网络中的miFC.
结论:
- 在休息状态下应用的非侵入性TI刺激可以急性调节前期海马体依赖的记忆任务所导致的功能连接 (FC) 痕迹.
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