喘,妊娠期糖尿病和不良周产期结果:基于人口的产科记录分析
Megan E Jensen1, Soriah Harvey1, Jason Dizon2
1School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia.
The journal of allergy and clinical immunology. In practice
|April 24, 2025
概括
喘和妊娠期糖尿病 (GDM) 在怀孕期间增加不良周产期风险,但双重暴露没有显示出协同效应. 在调整肥胖等混因素后,喘并没有增加GDM风险.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 喘和妊娠期糖尿病 (GDM) 是一种常见的孕期疾病.
- 两者都独立地增加了对周产期不良结果的风险.
- 喘和GDM同时发生对怀孕结果的影响以前是未知的.
研究的目的:
- 为了比较临床,人口和围产期结果.
- 在怀孕期间评估与喘和/或GDM相关的风险.
- 研究喘和GDM对围产期健康的综合影响.
主要方法:
- 来自澳大利亚卫生区 (2018-2020) 的单独出生数据的分析.
- 包括18岁及以上的母亲.
- 用于确定喘和/或GDM对围产期结果的影响的概括估计方程.
主要成果:
- 喘与GDM风险增加无关 (aRR为1.04;95% CI为0.96-1.13).
- 喘和/或GDM都独立增加了剖腹产和婴儿呼吸困难的风险.
- 喘与早产,低出生体重和先天性异常 (aRR 1.15) 的更高风险有关.
- 对喘和GDM的双重暴露增加了妊娠高血压疾病的风险 (aRR 1.36).
结论:
- 喘和/或GDM显著增加了周产期不良结果的风险.
- 对于喘和GDM的联合暴露,没有观察到协同的不良影响.
- 喘不是发展GDM的风险因素,当调整为诸如肥胖等混因素时.
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