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营养和炎症状况以及骨质疏松症和骨质疏松症患者的死亡结果之间的关联
Yazhou Liu1, Ying Yang2, Yuhao Li3
1Department of Orthopedics, Dalian Medical University, Dalian, China; Department of Orthopedics, Dandong Central Hospital, Dalian Medical University, Dandong, China.
The Journal of nutritional biochemistry
|April 24, 2025
概括
先进的肺癌炎症指数 (ALI) 与骨质疏松症患者的死亡率降低有关. 较高的ALI得分与该人群中所有原因和心血管死亡风险的降低相关.
科学领域:
- 老年学与公共卫生
- 骨代谢和炎症 骨代谢和炎症
背景情况:
- 骨质疏松症是一个主要的健康问题,增加骨折风险,特别是在老年人和营养不良的人群中.
- 系统性炎症,通常与营养不良有关,显著导致骨密度下降.
- 先进的肺癌炎症指数 (ALI) 是炎症和营养状况的公认标志物,但其在骨质疏松症预后中的作用未得到充分研究.
研究的目的:
- 调查高级肺癌炎症指数 (ALI) 与被诊断患有骨质疏松症的患者的死亡风险之间的关联.
- 评估ALI作为骨质疏松症患者队列中全因和心血管死亡率的预后指标的潜力.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) 的4,525名骨质疏松症患者 (2007-2023) 的数据的回顾性分析.
- 利用卡普兰-梅尔生存曲线,多变量考克斯回归和受限立方斜线图来评估ALI与死亡率的关系.
- 进行了子组和调解分析,以探索ALI在不同人口统计学中的预测作用及其对死亡率的调解作用.
主要成果:
- 在ALI得分和所有原因 (938例死亡) 和心血管死亡率 (223例死亡) 之间发现了显著的线性负相关性.
- 调解分析表明,ALI占骨质疏松症和全因死亡率之间的关联的4.9%,心血管死亡率为6.6%.
- 亚组分析证实了ALI对不同性别和身体活动水平的死亡率的预测能力.
结论:
- 先进的肺癌炎症指数 (ALI) 显示,骨质疏松症患者与所有原因和心血管死亡率有显著的线性负相关性.
- 作为一个有价值的预后生物标志物来评估骨质疏松症患者的死亡风险,ALI显得有前途.
- 研究结果表明,ALI反映的炎症和营养状况在骨质疏松症的长期结果中起着关键作用.
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