在低收入和中等收入国家环境中使用实用解释型连续性指标总结工具:系统审查
Timo Tolppa1, Arishay Hussaini2, Maham J Ahmed2
1Department of Experimental Medicine, University of British Columbia, 10th Floor, Room 10117, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada.
实用解释连续性指标摘要 (PRECIS) 工具对于低收入和中等收入国家 (LMICs) 的研究是有价值的,但需要改进以获得更广泛的全球适用性和一致的报告.
科学领域:
- 医疗保健服务研究 医疗服务研究
- 临床试验设计 临床试验设计
- 全球健康 全球健康
背景情况:
- 实用解释连续性指标摘要 (PRECIS) 工具有助于设计研究,以平衡内部有效性与外部适用性.
- 关于在低收入和中等收入国家 (LMICs) 应用PRECIS工具的现有文献需要系统审查,以确定成功和挑战.
研究的目的:
- 系统地审查和描述关于在LMICs中使用PRECIS工具的文献.
- 确定成功,挑战和需要改进的领域,以提高PRECIS工具在各种全球环境中的适用性.
主要方法:
- 在PubMed的系统文献搜索中,寻找有关LMIC研究中的PRECIS工具的同行评审文章.
- 数据提取集中在试验特征,修改和PRECIS工具应用上.
- 叙事综合概述发现,挑战和建议.
主要成果:
- 40篇文章符合选择标准;PRECIS工具主要用于超出初始试验设计 (97.5%) 的目的.
- PRECIS-2是最常用的版本 (80%),用于量化实用性和评估试验设计.
- 挑战包括主观性,数据不可用,解释问题以及在非西方和跨国环境中的应用.
结论:
- PRECIS工具是可靠的,并支持全球研究,尽管经常用于意想不到的目的.
- 建议对评分标准,翻译和教育资源进行改进,以实现一致的应用和报告.
- 对于LMIC的具体考虑包括适应传统医学,国际试验和研究原始环境.
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