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多发性硬化症中自主神经系统异常的演变:六年随访
Berislav Ruška1, Ivan Adamec2,3, Luka Crnosija2
1Department of Neurology, University Hospital "Sveti Duh", Zagreb, Croatia.
Journal of neurology, neurosurgery, and psychiatry
|April 24, 2025
概括
多发性硬化症 (MS) 中的自主功能障碍 (AD) 在六年内进展,影响心血管和运动系统. 早期高效疗法可能会降低MS患者的AD风险.
科学领域:
- 神经学 神经学
- 自主神经系统研究 自主神经系统研究
- 多发性硬化症研究研究
背景情况:
- 缺乏对多发性硬化症 (pwMS) 患者自主功能障碍 (AD) 的长期研究.
- 这项研究调查了从疾病发作开始的六年时间内,pwMS中AD的进展和预测因素.
研究的目的:
- 在pwMS中随着时间的推移探索自主功能的变化.
- 为了确定自主功能障碍发展和 pwMS 进展的预测因素.
主要方法:
- 研究了121名pwMS队列,其中75名在基线和6年接受自主功能测试.
- 使用复合自主系统得分-31 (COMPASS-31) 评估自主症状,并使用复合自主评分表 (CASS) 记录自主测试结果.
- 症状性自主障碍是由特定的COMPASS-31和CASS得分值定义的.
主要成果:
- 虽然总体的COMPASS-31和CASS评分没有显著变化,但心血管和运动指数在4年和6年显著下降.
- 症状性dysautonomia的患病率显著增加,从基线20.9%增加到6.年39.2%.
- 经历复发增加了症状性dysautonomia的可能性,而过渡到高效疾病修饰疗法 (HET) 降低了积极CASS分数的概率.
结论:
- 在pwMS中,心血管和运动系统功能障碍随着疾病持续时间的推移而进展.
- 早期启动高效疾病修饰疗法 (HET) 可能是减轻发展自主功能障碍的风险的一种策略.
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