肥胖影响血清Klotho和与年龄相关的听力损失之间的联系:一个横截面研究
Jingchao Yan1, Ling Li1, Qing Ye1
1Department of Pharmacy, Eye & ENT Hospital, Fudan University, Shanghai, China.
Obesity research & clinical practice
|April 24, 2025
概括
肥胖影响了Klotho和与年龄相关的听力损失 (ARHL) 之间的联系. 在非肥胖个体中,较高的Klotho水平与较低的ARHL风险相关,但这种关联在肥胖中不存在.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 与年龄相关的听力损失 (ARHL) 是一个日益严重的公共卫生问题,特别是在老年人群中.
- 克洛托是一种蛋白质激素,在衰老中发挥作用,并与各种与年龄相关的疾病有关.
- 肥胖对Klotho和ARHL之间的关系的影响仍未得到充分研究.
研究的目的:
- 调查肥胖对血清Klotho水平与与年龄相关的听力损失 (ARHL) 患病率之间的关系的影响.
- 在非肥胖和肥胖群体中分析血清Klotho和ARHL之间的相关性.
主要方法:
- 分析了3355名参与国家健康和营养检查调查 (NHANES) 的数据.
- 参与者的分层分为非肥胖 (BMI <30 kg/m2) 和肥胖 (BMI ≥30 kg/m2) 的组.
- 多变量逻辑回归和受限制的立方线,以评估血清Klotho和ARHL之间的相互作用和剂量反应关系.
主要成果:
- 在非肥胖的参与者中观察到血清Klotho水平和ARHL之间的显著逆相关性 (OR = 0.88,95%CI 0.79-0.99,p=0.034).
- 在非肥胖组中证实了血清Klotho和ARHL之间的线性关系.
- 在肥胖群体中,血清Klotho水平和ARHL之间没有显著的关联.
结论:
- 肥胖似乎显著调节了血清Klotho水平和与年龄相关的听力损失之间的关系.
- 这些发现表明,肥胖可能会破坏Klotho对听力损害的保护性关联.
- 了解这种相互作用可以为预防和管理不同人群中的听力损失提供有针对性的策略.
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